![]() Through our STAR (Signal, Transduction, Activity, and Response) Drug Discovery Platform, we studied the effects of three hundred medicinal plant extracts across 25 signaling pathways to identify a drug candidate. Developing a multi-targeted drug that can inhibit both the AR variant and GR action could help overcome drug resistance, increase durability, and improve the therapeutic outcome for prostate cancer patients. AR variants and glucocorticoid receptor (GR) (replacing AR function) are two key factors to promote resistance to AR-targeting therapies in CRPC patients. Androgen or Androgen receptor (AR) targeted therapy is a strategy for the treatment of prostate cancer, however, long-term treatment with androgen deprivation therapy inevitably leads to the development of Castration-Resistant Prostate Cancer (CRPC). Send us feedback about these examples.Prostate cancer is the second leading cause of cancer death among men in the United States. ![]() These examples are programmatically compiled from various online sources to illustrate current usage of the word 'bookend.' Any opinions expressed in the examples do not represent those of Merriam-Webster or its editors. 2023 Today is unusual in that two launches bookend the workday. Bill Goodykoontz, The Arizona Republic, 18 Jan. 2023 The comic book instead uses Griner’s harrowing time there to bookend the story, the rest of which is autobiographical. Matt Murschel, Orlando Sentinel, 28 Mar. 2023 Payton’s emergence has the redshirt sophomore in the mix to bookend with Verse while the addition of Edmond provides another versatile pass rusher. 2021 To bookend the year, a similar event, Suwannee Roots Revival, occurs in October. 2021 During the therapy sessions that bookend it, Clarice’s therapist (Shawn Doyle) stares straight into the camera, his face filling up the screen. Claire Shaffer, Rolling Stone, 1 July 2021 One great idea is to bookend your trip with waterfall hikes. Jeff Metcalfe, The Arizona Republic, 29 July 2021 Rather than perform the entire Side Two medley from the original Beatles album, the tenacious duo bookend their single with semi-faithful renditions of the two songs, and fill in the gaps with some absurd verses and scatting of their own. Verb So even given his lofty ranking, there is ample room for Thomas to bookend his 2017 PGA Championship title with an Olympic medal on the career achievement mantle. 2022 Perhaps this is a bookend to Yehoshua: a sci-fi classic in which two young siblings flee danger in a future Africa. 2022 His bookend was the 6-0 sophomore Pullian, who had 11 points, a game-high eight rebounds and three assists in 20 minutes. ![]() Lila Bromberg, Hartford Courant, 31 Dec. 2023 The UConn women’s basketball team put a bookend on 2022 with another shorthanded victory on Saturday. 2023 Share Toshiba’s sale was supposed to be a bookend to years of corporate governance reforms in Japan The long-running saga of Toshiba TOSYY -3.98%decrease red down pointing triangle is finally coming to an end. Jennifer Jenkins, Harper's BAZAAR, 6 Mar. 2023 Echoing that theme, the bookend rings can be used to complete your favorite ring stack at each end. 2023 Both Christian symbols are bookends to the Easter story. 2023 The 31-year-old winger’s quick shot from the slot was an unceremonious bookend to a miserable night on Causeway Street for the Bruins. Jr Radcliffe, Journal Sentinel, 27 Apr. Noun Sure enough, the famous footage from the 2007 NFL draft now serves as a perfect bookend to his Hall of Fame induction, coming up Aug.
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